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pentobarbital will reduce the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Keep track of.Keep an eye on Closely (1)pentobarbital will reduce the level or effect of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Loss of, or reduced reaction to tofacitin